Pubdate: Sat, 15 Jul 2000
Source: Las Vegas Weekly (NV)
Copyright: 2000 Radiant City Publications, LLC
Contact:  P.O. Box 230657, Las Vegas, NV 89123-0011
Fax: (702) 990-2424
Website: http://www.lasvegasweekly.com/
Author: Raymond Cushing

IN A HAZE

Nearly Three Decades Ago The Government Knew Marijuana Could Help Cure
Cancer; The Rest Of Us Are Just Finding Out Now

The term medical marijuana took on dramatic new meaning in February
when researchers in Madrid announced they had destroyed incurable
brain cancer tumors in rats by injecting them with THC, the active
ingredient in cannabis. The Madrid study marks only the second time
that THC has been administered to tumor-bearing animals; the first was
a Virginia investigation 26 years ago. In both studies, the THC shrank
or destroyed tumors in a majority of the test subjects.

Most Americans don't know anything about the Madrid discovery.
Virtually no U.S.  newspapers carried the story, which ran only once
on the AP and UPI news wires, on Feb. 29.

The ominous part: This isn't the first time scientists have discovered
that THC shrinks tumors.

In 1974, researchers at the Medical College of Virginia, who had been
funded by the National Institute of Health to find evidence that
marijuana damages the immune system, found instead that THC slowed the
growth of three kinds of cancer in mice --lung and breast cancer, and
a virus-induced leukemia.

The ED quickly shut down the Virginia study and all further
cannabis/tumor research, according to Jack Herer, who reports on the
events in his book, The Emperor Wears No Clothes. In 1976, President
Gerald Ford put an end to all public cannabis research and granted
exclusive research rights to major pharmaceutical companies, who set
out--unsuccessfully--to develop synthetic forms of THC that would
deliver all the medical benefits without the "high."

The Madrid researchers reported in the March issue of Nature Medicine
that they injected the brains of 45 rats with cancer cells, producing
tumors whose presence they confirmed through magnetic resonance
imaging (MRI). On the 12th day they injected 15 of the rats with THC
and 15 with Win-55,212-2--a synthetic compound similar to THC.

"All the rats left untreated uniformly died 12-18 days after gloom
(brain cancer) cell inoculation ... Cannabinoid (THC)-treated rats
survived significantly longer than control rats. THC administration
was ineffective in three rats, which died by days 16-18. Nine of the
THC-treated rats surpassed the time of death of untreated rats, and
survived up to 19-35 days. Moreover, the tumor was completely
eradicated in three of the treated rats." The rats treated with
Win-55,212-2 showed similar results.

The Spanish researchers, led by Dr. Manuel Guzman of Complu-tense
University, also irrigated healthy rats' brains with large doses of
THC for seven days, to test for harmful biochemical or neurological
effects. They found none.

"Careful MRI analysis of all those tumor-free rats showed no sign of
damage related to necrosis, edema, infection or trauma ... We also
examined other potential side effects of cannabinoid administration.
In both tumor-free and tumor-bearing rats, cannabinoid administration
induced no substantial change in behavioral parameters such as motor
coordination or physical activity.

Food and water intake as well as body weight gain were unaffected
during and after cannabinoid delivery. Likewise, the general
hematological profiles of cannabinoid-treated rats were normal.

Thus, neither biochemical parameters nor markers of tissue damage
changed substantially during the 7-day delivery period or for at least
two months after cannabinoid treatment ended."

Guzman's investigation is the only time since the 1974 Virginia study
that THC has been administered to live tumor-bearing animals. (The
Spanish researchers cite a 1998 study in which cannabinoids inhibited
breast cancer cell proliferation, but that was a "petri dish"
experiment that didn't involve live subjects.)

Guzman says he has heard of the Virginia study, but has never been
able to locate literature on it. Hence, the Nature Medicine article
characterizes the new study as the first on tumor-laden animals and
doesn't cite the 1974 Virginia investigation.

"I am aware of the existence of that research.

In fact I have attempted many times to obtain the journal article on
the original investigation by these people, but it has proven
impossible." Guzman says.

In 1983 the Reagan/Bush Administration tried to persuade American
universities and researchers to destroy all 1966-76 cannabis research
work, including compendiums in libraries, reports Jack Herer, who
states, "We know that large amounts of information have since
disappeared."

Guzman provided the title of the work--"Antineoplastic activity of
cannabinoids," an article in a 1975 Journal of the National Cancer
Institute--and this writer obtained a copy at the UC medical school
library in Davis and faxed it to Madrid.

The summary of the Virginia study begins, "Lewis lung adenocarcinoma
growth was retarded by the oral administration of tetrahydrocannabinol
(THC) and cannabinol (CBN)"--two types of cannabinoids, a family of
active components in marijuana. "Mice treated for 20 consecutive days
with THC and CBN had reduced primary tumor size."

The 1975 journal article doesn't mention breast cancer tumors. But an
article in the Washington Post, dated Aug. 18, 1974--the only
newspaper story ever to appear about the 1974 study--does mention
THC's effects on breast cancer.  Under the headline, "Cancer Curb Is
Studied," it read in part: "The active chemical agent in marijuana
curbs the growth of three kinds of cancer in mice and may also
suppress the immunity reaction that causes rejection of organ
transplants, a Medical College of Virginia team has discovered." The
researchers "found that THC slowed the growth of lung cancers, breast
cancers and a virus-induced leukemia in laboratory mice, and prolonged
their lives by as much as 36 percent."

Guzman was eloquent in his response after he was faxed the clipping
from the Washington Post of a quarter century ago. In translation, he
wrote:

"It's extremely interesting to me, the hope that the project seemed to
awaken at that moment, and the sad evolution of events during the
years following the discovery, until now we once again 'draw back the
veil' over the anti-tumoral power of THC, 25 years later.
Unfortunately, the world bumps along between such moments of hope and
long periods of intellectual castration."

News coverage of the Madrid discovery has been virtually nonexistent
in this country.

The news broke quietly on Feb. 29 with a story that ran once on the
UPI wire about the Nature Medicine article.

I stumbled on it through a link that appeared briefly on the Drudge
Report web page. The New York Times, Washington Post and Los Angeles
Times all ignored the story, even though its newsworthiness is
indisputable: a benign substance occurring in nature destroys deadly
brain tumors.

If that's not page one, what is?
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