Pubdate: Thu, 19 Jul 2001 Source: Reuters (Wire) Copyright: 2001 Reuters Limited Author: Alan Elsner, National Correspondent EXPERTS SAY U.S. USE OF ECSTASY DRUG RISES SHARPLY BETHESDA, Md, July 19 (Reuters) - Use of the drug ecstasy is exploding among young people in the United States and could become as destructive as the crack cocaine epidemic that swept the country 20 years ago, a conference heard on Thursday. The international conference at the National Institutes of Health outside Washington coincided with the introduction of bipartisan legislation in the U.S. Senate to boost education efforts against the drug and set up a federal task force to coordinate efforts to combat it. "Ecstasy dealers are selling the lie that by taking ecstasy, young people can get high without harming themselves," said Sen. Bob Graham, a Florida Democrat who is the chief architect of the bill. "But the truth is, what we know about the effects of ecstasy on the brain is frightening. And what we don't know is likely to be more so. We need to get the word out and fast, before one more teen-ager 'raves' himself to death," he said. The explosion in Ecstasy use means a large population of young Americans may be prone to cognitive impairment and depression in years to come, experts say. Known as "E" or "X" by its users, the drug's full scientific name is 3-4 methylenedioxymethamphetamine. Most scientists usually refer to it as MDMA. RECALLS DEADLY CRACK EPIDEMIC On Wednesday, New York City police seized 1 million ecstasy pills worth $40 million from a Manhattan apartment, the largest ecstasy bust ever in the city. But New York Democratic Sen. Hillary Rodham Clinton said approximately 2 million pills were believed to move through New York airports into the country every week. James Hall, who directs a drug information center in Miami, told the conference use of MDMA was following a similar trajectory to that of the crack cocaine epidemic that swept the United States in the 1970s and 1980s. Once confined to small sub-cultures, the drug was breaking out into the general population, being sold in schools, gas stations and on street corners as well as at clubs and all-night music parties, known as "raves." One notable aspect of ecstasy use is that users often combine the drug with other substances, including heroin, marijuana, other designer drugs and alcohol. Jean Schensul, conducting a study of ecstasy use among urban youth in Hartford, Connecticut, said the drug, formerly used almost exclusively by white youths, had become popular in black and Hispanic populations, pushed by hip-hop magazines and rap musicians. "MDMA has become big business in urban neighborhoods today," she said. The conference, due to run through Friday, was scheduled to hear the latest evidence that ecstasy may well cause permanent brain damage. "In the short term, ecstasy can cause dramatic changes in heart rate and blood pressure, dehydration and a potentially life-threatening increase in body temperature," said Alan Leshner, director of the National Institute on Drug Abuse. "In the longer term, research shows that ecstasy can cause lasting changes in the brain's chemical systems that control mood and memory," he said. RISK OF MEMORY LOSS, DEPRESSION H. Valerie Curran, a researcher from University College, London, said animal experiments showed conclusively that brain damage resulted from even small amounts of the drug and lasted for years. Among humans, there was strong evidence of memory impairment that persisted after they stopped taking MDMA. "It could mean that a very large population using ecstasy might be prone to cognitive impairment and depression in years to come," she said. Harvard Medical School researcher Patricia Case, who conducted a study of MDMA use among homosexuals in New York and Boston, said almost all the men in her sample were using the drug in association with a cocktail of other drugs. Such cocktails were known as "trail mix." Most snorted the drug using a device called a "bumper." Robert Carlson, of Wright States University in Dayton, Ohio, said young people overwhelmingly saw MDMA as a benign drug and did not believe warnings that it was dangerous. "Convincing young people there is a major health risk is a major challenge to future prevention efforts," he said. - --- MAP posted-by: Jay Bergstrom