Pubdate: Mon, 26 Aug 2002
Source: Globe and Mail (Canada)
Copyright: 2002, The Globe and Mail Company
Contact:  http://www.globeandmail.ca/
Details: http://www.mapinc.org/media/168
Author: Marni Jackson
Note: Marni Jackson is the author of Pain: The Fifth Vital Sign.

SMOKE OUT THE POLITICIANS

Last week, the same day that Health Minister Anne McLellan suggested 
shelving medical marijuana, I was at the World Pain Congress in San Diego, 
Calif., listening to the first plenary session on pain and cannabinoids 
(the molecules that count in cannabis). There were about 5,000 pain 
scientists in one very large room, most of whom were familiar with the 
evidence that cannabis can relieve pain. Old news.

But what I also learned might shock our squabbling politicians. When it 
comes to the cannabinoids, we are already growing our own -- inside the 
body. How do we regulate that?

The same substance in cannabis that can help people with multiple sclerosis 
deal with muscle spasms, or cancer patients deal with nausea, is also 
present in human breast milk. Endogeneous cannabinoids, as they're known, 
are part of the body's own pain-killing resources -- cousins to more 
familiar ones, such as endorphins. Receptors for cannabinoids, in the 
brain, spine and peripheral nerves, have just been discovered in the past 
decade.

This is the science end of things. But we have a tendency to think about 
drugs superstitiously, dividing them into "natural" versus "synthetic," or 
heroic (anticancer drugs) versus sinister (narcotics and cannabis). The 
fact is that most drugs, regardless of the reassuring bubble packs we buy 
them in, are synthesized from plants or pods or pretty flowers. Drugs are 
not alien invaders; they often mimic or amplify perfectly natural 
mechanisms in the body. And the reason that opiates and marijuana work 
against pain (in quite distinct ways) is that they match substances that 
the body already creates. Strictly speaking, we all use dope.

Some scientists even believe that cannabis could be more useful for certain 
difficult kinds of neurological pain than opiates. This was the opinion of 
Andrew Rice, senior lecturer in pain research from Imperial College in 
London, England, when he gave his plenary address in San Diego.

Dr. Rice began by pointing out that cannabis has been used for pain relief 
for centuries. Evidence of smoked marijuana was found beside the body of a 
woman who died in childbirth more than two centuries ago. Queen Victoria 
used cannabis for her menstrual cramps (she was a big fan of ether for 
childbirth, too). In studies that use synthetic cannabinoids, very small 
doses have been shown to offer pain relief. Dr. Rice reported that "We are 
just beginning to discover the importance of the endocannabinoids [the 
home-grown stuff]."

The aim now is to develop a synthetic version that would divorce the 
analgesia from the high, because not everybody in pain wants that -- it 
tends to increase the Dorito intake, for one thing; besides, inhaling smoke 
has its health risks too.

Dr. Rice concluded that although there was lots of laboratory data to 
support the use of cannabis for pain relief, its clinical use was 
premature. Why? "This is probably much more of a political question than a 
medical matter," he said.

It's a question of access, in other words.

When Ms. McLellan says Canada should shelve the use of medical marijuana 
until further studies, she is depriving science of one very good avenue of 
research -- the experience of people in pain who are already using 
marijuana and benefiting from it.

Mark Ware, associate professor of anesthesia at McGill University and a 
pain physician, has done work on the therapeutic potential of cannabis. In 
a study presented at the congress (one of 16 papers on the subject), Prof. 
Ware followed a group of chronic pain patients who used marijuana. They all 
reported decreased pain, and most found it helped them relax and get to 
sleep. "What was interesting was how effective a low dose of marijuana 
could be," he pointed out. "The doses were variable but some got relief 
from as little as two or three puffs a day."

The amount of cannabis useful for pain relief, in other words, doesn't 
resemble the Cheech and Chong quantities that its opponents imagine. Nor 
does everyone want the high; their aim is to reduce suffering and get on 
with life.

Because these drugs are so promising in terms of health and economic 
benefits, it's important not to slow down research on them. Besides, 
cannabis can even lead to decreased drug use in patients. "One great 
advantage of using cannabinoids for pain relief," says Dr. Jim Henry, 
director of the Canadian Pain Consortium and another researcher in this 
area, "is that when you combine them with opiates, patients can lower their 
dosage of these drugs."

So why has Ms. McLellan chickened out on the marijuana front? Dr. Harold 
Merskey, an internationally recognized pain researcher in London, Ont., 
told me: "I suspect our politicians don't want to be ahead of America in 
this matter, because it raises a sensitive border issue." Namely, the fear 
of Americans flocking across the border to avail themselves of high-grade, 
government-issue cannabis.

But if Canada puts this sort of fear ahead of the therapeutic potential to 
ease suffering, we will be headed toward a mini-version of America's War on 
Drugs -- a campaign that has been a ruinous and costly failure in 
addressing the serious issue of addiction and drug abuse.

It's ironic: Canada has the legal framework in place, lots of impressive 
research on hand -- but we're going to sit on it. Meanwhile, people with 
cancer, AIDS, MS, or severe arthritis, who could benefit from a puff or two 
a day, and who may not have the luxury of worrying about long-term effects, 
have been deprived of a cheap painkiller that has not caused a single 
fatality (unlike anti-inflammatories, which were linked with 20,000 deaths 
in the United States last year). Marijuana also looks quite nice growing in 
a window box.

Cannabis has risks, as all drugs do. We don't yet know its long-term 
effects on memory or the immune system. But hormone-replacement therapy has 
its proven dangers too, and the government hasn't bestirred itself to 
shelve premarin.

So let's do the clinical trials to measure long-term consequences. And by 
all means, let's develop a cannabinoid that cleanly targets pain without 
the high. (How Canadian: a drug that makes you feel normal.)

Canadian cannabis has a nice brand-ish ring to it. If the maple leaf went 
on a diet, it might even resemble the leaf in question.

But in the meantime, let's not deprive ourselves of the one population that 
could offer us crucial evidence about the pros and cons of its use -- 
namely, the roughly 400,000 Canadians who already use marijuana for pain 
relief. For them, the main pain now is access.
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MAP posted-by: Alex