Pubdate: Fri, 14 Oct 2005
Source: Regina Leader-Post (CN SN)
Copyright: 2005 The Leader-Post Ltd.
Contact:  http://www.canada.com/regina/leaderpost/
Details: http://www.mapinc.org/media/361
Author: Janet French, CanWest News Service

RESEARCH SEES BENEFITS OF MARIJUANA-LIKE DRUG

A University of Saskatchewan team has shown that a pot-like drug
reduces the symptoms of anxiety and depression in rats.

Using injections of a synthesized substance called HU210, which mimics
one of the active ingredients in marijuana, Dr. Xia Zhang, an
associate professor of psychiatry, and his colleagues showed new
growth of brain cells increased in rats.

Other recent studies have linked that growth, or so-called
neurogenesis, to a reduction in anxiety and depression.

The results were published Thursday on the Web site of the Journal of
Clinical Investigation.

"The implication of this paper is that smoking marijuana is a good
thing," Zhang said with a hearty laugh in his office.

The group, including researchers at Xijing Hospital in China and at
the University of Maryland in Baltimore, have yet to test the effect
of marijuana itself on rats' neurogenesis, Zhang said.

He also cautions against the assumption the drug will have the same
effect on humans.

"There is a big gap between rats and humans," Zhang said.
"Realistically, we cannot judge these results from rats and apply them
to a human situation. There's a huge difference. Our results can give
(only) some indication or implication."

Although previous studies have shown alcohol, nicotine, opiates and
cocaine reduce the growth of new brain cells, Zhang's paper is the
first to show marijuana could have the opposite effect.

Because rats can't say how depressed they are, researchers used tests
such as putting the rats in a swimming pool with no escape to see how
quickly they would give up swimming and resign themselves to a likely
fate of drowning.

What's more exciting to researchers than the potential connection
between smoking pot and easing lethargy and frayed nerves is the
possibility a component of marijuana could be the next blockbuster
antidepressant.

"Prozac is great, but it does have its problems, and its mechanism of
action is similar to antidepressants we were using 40, 50 years ago,"
said Dr. Lisa Kalynchuk, a Canada Research Chair in behavioural
neuroscience and associate professor of psychology at the University
of Saskatchewan. 
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