Pubdate: Tue, 08 Nov 2005 Source: Sun-Sentinel (Fort Lauderdale, FL) Copyright: 2005 Sun-Sentinel Company Contact: http://www.sun-sentinel.com/ Details: http://www.mapinc.org/media/159 Author: Thomas H. Maugh II, LA Times Staff Writer Bookmark: http://www.mapinc.org/meth.htm (Methamphetamine) SYPHILIS, DRUG-RESISTANT GONORRHEA ON THE RISE Gay males undertaking risky sexual activity are fueling two disturbing trends in sexually transmitted diseases: a sharp increase in the incidence of syphilis and a smaller but concerning rise in the transmission of gonorrhea resistant to commonly used antibiotics, federal researchers said today. Those increases come at a time when STD rates among historically important risk groups, especially women and minorities, have declined, according to a new report from the Centers for Disease Control and Prevention. STDs "are a significant and ongoing threat to millions of Americans, especially young men," said Dr. Ronald Valdiserri, acting director of CDC's National Center for HIV, STD and TB Prevention. Health authorities made major inroads into syphilis transmission during the 1990s, bringing the annual number of new cases during 2000 to the lowest level since record-keeping began in 1941. Between 2000 and 2004, however, the rate rose by 81% to a U.S. total of 7,980 cases. Men who have sex with men accounted for 64% of the syphilis infections in 2004, compared to only about 5% of them in 1999, said Dr. John Douglas, director of the CDC's division of STD prevention. The absolute number of cases may seem small, but the data is potentially alarming, experts said, because increases in STD transmission are generally assumed to be precursors of increases in the transmission of the AIDS virus, which is much more difficult to combat. "We have very good and sound information showing increases in high-risk behaviors among men having sex with men since 1999," fueling the increase in syphilis, Valdiserri said. Increases in risky behavior, in turn, are being accelerated by the epidemic of crystal methamphetamine use, he added - first on the west coast and now spreading to the East. "That's exacerbating the transmission of syphilis," he added. Gonorrhea rates have fallen to 113.5 cases per 100,000 people in 2004 - - about 330,000 cases - the lowest rate since 1941. Nonetheless, surveillance by CDC in selected cities has shown that resistance to fluoroquinolone antibiotics - the common first-line treatment for gonorrhea - increased from 4.1% in 2003 to 6.8% in 2004. Most disturbing, the rate of antibiotic resistance among men having sex with men was 23.8%, eight times the rate in heterosexuals. Last year, CDC recommended that fluoroquinolones no longer be used to treat the disease in men having sex with men. They are also not recommended for use in California and Hawaii, where resistance has been widespread for years. The reported incidence of chlamydia also rose 5.9% last year to 319.6 cases per 100,000 people - a total of 929,462 cases. But Valdiserri and Douglas attributed much of that growth to new and more aggressive screening programs rather than to increased transmission. Nonetheless, the report says that the majority of cases are still not detected or reported to the agency, and that the actual number of infections is as high as 2.8 million cases per year. "Health care providers urgently need to step up screening for chlamydia, particularly among young, sexually active women, who are at greatest risk of infertility if the disease is not diagnosed and treated," Douglas said. The two other most common STDs in the United States, herpes and human papilloma virus, are not reported to federal authorities, although good estimates of their prevalence are available from other sources. Taking them in account, Valdiserri said, the total number of STDs in the United States each year is about 19 million, almost half of them among people ages 15 to 24. - --- MAP posted-by: Beth Wehrman