Pubdate: Tue, 03 Oct 2006
Source: BBC News (UK Web)
Copyright: 2006 BBC
Website: http://news.bbc.co.uk/

OVEREATING 'LIKE DRUG ADDICTION'

For Obese People Overeating Is Akin To Drug Addiction, Research Suggests.

Scans on seven overweight people revealed the regions of the brain 
that controlled satiety were the same as those in drug addicts craving drugs.

The US team who carried out the research said the findings could 
potentially help to uncover new treatments for obesity.

The work, led by a New York scientist, is published in the 
Proceedings of the National Academy of Sciences.

The researchers looked at brain impulses in seven overweight individuals.

They had all been previously fitted with a weight-reduction device 
called an implantable gastric stimulator (IGS).

The implant sends electronic signals to the vagus nerve which then 
relays messages of satiety to the brain, thus reducing the desire to eat.

To study the interaction between the stomach and the brain, the 
volunteers received two brain scans spaced two weeks apart, one when 
the implant was turned on and the other while it was switched off.

New Channels

While the volunteers were feeling full and the implant was turned on, 
the scan revealed an increased metabolism in the hippocampus, an area 
of the brain associated with emotional behaviour, learning and 
memory, the orbitofrontal cortex and the striatum.

Lead researcher Dr Gene-Jack Wang, at the Brookhaven National 
Laboratory, New York, said: "As soon as we saw these scans, 
immediately it reminded me of what we had studied in drug abuse when 
people were under a craving situation - the same areas in the brain lit up."

He said this supported the idea that there were commonalities in the 
brain circuitry that underlay food intake and compulsive drug intake.

Although the study was small, he added, it would help to further 
understand the desire to eat and obesity.

"It gives us another channel to understand how to treat or prevent obesity."

Professor Jimmy Bell, of the molecular imaging group at Hammersmith 
Hospital, said: "This is a very interesting paper.

"There is a lot of research going on around the world looking for 
biomarkers - anything that will tell you directly what is going on in 
a biological process - to understand the relationship between 
appetite, satiety and emotional factors that control what we eat, and 
when we eat and how much we eat.

"I do not think it is surprising they have found a link between drug 
addiction and overeating. In a way you can think of eating as a 
'necessary addiction' - if we were not addicted to eating, most of us 
would stop eating."
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