Pubdate: Sun, 21 May 2006 Source: Tribune Review (Pittsburgh, PA) Copyright: 2006 Tribune-Review Publishing Co. Contact: http://www.pittsburghlive.com/x/tribune-review/trib/ Details: http://www.mapinc.org/media/460 Author: Jill King Greenwood Bookmark: http://www.mapinc.org/topics/Salvia Bookmark: http://www.mapinc.org/hallucinogens.htm (Hallucinogens) TRIPPIN' WITH 'SALLY D' When people first started asking Ivan Harris if he stocked Salvia divinorum at his Squirrel Hill smoke shop, he had no idea what they wanted. "I hadn't heard of it," said the owner of the Continental Smoke Shop Ltd. on Murray Avenue. "But I did some research, and this stuff looks pretty bad." Salvia divinorum (pronounced SAL-vee-ah div-en-OR-um) is a recreational drug that people can obtain legally in Pennsylvania and most other states -- at least for now. The botanist who sells it on the Internet says it's a harmless way to meditate and clear the mind, but others say the drug is dangerous and gives users a potent hallucinogenic high comparable to LSD. The parents of a 17-year-old Delaware teen are blaming Salvia for their son's January suicide. The drug, a perennial herb in the mint family native to parts of the Sierra Mazateca region of Oaxaca, Mexico, is legal. It can be purchased on the Internet, and in some states it's found at pharmacies and grocery stores. But three states have banned its use and sale, and similar legislation is pending in five other states. Countries, including Australia and Denmark, also have banned it, and legislators in Pennsylvania are reviewing it. The federal Drug Enforcement Administration added it to its "drugs of concern" list two years ago. Mike Piecuch, chief counsel to the Pennsylvania House Judiciary Committee, said several legislators have questioned what should be done about Salvia. "It's a psychoactive drug and it's being marketed as a recreational drug," Piecuch said. "It's very troubling and we are concerned." Dr. Neil Capretto, medical director of Gateway Rehabilitation Centers in Pittsburgh, said a few people who sought treatment during the past year mentioned using Salvia, but none called the herb a "drug of choice." "It definitely worries me," Capretto said. "People portray it as a wonderful thing to heighten your awareness and get in touch with your spiritual senses, but people have had terrifying, nightmarish experiences with it. It's too unpredictable. It's like playing Russian roulette." Though Capretto and local law enforcement officials said they've heard little about people using Salvia -- sometimes called "Sally D" or "Maria Pastora" in this area -- its popularity has grown nationwide. "We have heard more about it in the past few years," said Dave Ausiello, spokesman for the federal Drug Enforcement Administration in Washington, D.C. "Any drug marketed heavily on the Internet will gain in popularity. But just because it's legal and you can buy it online doesn't mean it's safe. Parents should be very concerned and aware." The drug has been used for centuries by Mazateca Indians and shamanic healers as a meditative and healing tool, but was only discovered by outsiders in the 1960s. It remained relatively obscure until it hit the Internet in the 1990s. Thomas Prisinzano, a medical researcher at the University of Iowa who has studied Salvia, said typing "Salvia" into an Internet search engine can yield 10,000 hits, most of which are for head shops -- places that sell pipes and tobacco. "That many hits means that people will start to abuse it," Prisinzano said. The drug does have legitimate research purposes. Prisinzano is studying whether the active ingredient in Salvia -- Salvinorin A -- could be used to create a nonaddictive painkiller. Researchers are trying to understand how Salvia produces hallucinations in the brain as a path to better understand Alzheimer's disease and other mental illnesses, Prisinzano said. Dr. Bryan Roth, professor of biochemistry, psychiatry and neurosciences at Case Western Reserve University in Ohio, discovered in 2002 how Salvinorin A travels through the brain. Roth said the drug has become "a hot area of research right now" and said scientists, including himself, are studying whether it can be used to combat depression, chronic pain and kidney problems. Even so, Roth supports regulation of the sale and use, similar to restrictions on the purchase of alcohol and tobacco products. "Some people have incredibly damaging, frightening experiences because this stuff is just so incapacitating," Roth said. "They take it and they have no idea where they are or what they're doing, so they could wander into the street, fall off a building or try to drive a car and hurt someone. It's troubling." Roth said one user told him that in her hallucination, she found herself in a room with several doors and an alternate future behind each one. She chose a door and saw the death of her child, he said. Daniel Siebert, a botanist in Malibu, Calif., who has smoked Salvia on and off for two decades and was the first to identify the Salvinorin A ingredient, said when he smokes the herb he retreats into a deep meditative state and replays scenes from his childhood. Siebert, 45, said he has "visions and images, and things similar to a natural dreamlike state. It's very comfortable and familiar." Siebert sells the drug online and runs a clearinghouse information Web site on Salvia, but said he doesn't want to see "children and teenagers" using it. The herb costs as little as $4 a gram for a whole leaf. For crushed leaves or extract of the herb, prices range from $20 to $60 depending on the potency. Users chew the leaf or roll the crushed leaves and smoke them or use a water pipe, Prisinzano said. One "hit" from a water pipe can yield hallucinations that last up to an hour, he said, but most users experience effects for 15 to 30 minutes. The drug is not addictive, Siebert maintains, but Ausiello said DEA scientists are studying the herb to see if the evidence supports his claim. Studies on animals have linked the drug to depression, Ausiello said, but experts don't know the long-term effects of using Salvia. "If anything, it has the opposite effect of addiction," Siebert said. "Many people try it and they hate it and say there's no way they're doing that again. It is incredibly intense and it's not pleasant to many people. But I think, overall, that Salvia has been misrepresented." - --- MAP posted-by: Richard Lake