Pubdate: Fri, 02 Jun 2006
Source: BBC News (UK Web)
Copyright: 2006 BBC
Website: http://news.bbc.co.uk/
Bookmark: http://www.mapinc.org/mmj.htm (Cannabis - Medicinal)
Bookmark: http://www.mapinc.org/find?323 (GW Pharmaceuticals)

CANNABIS 'REDUCES SURGERY PAIN'

A cannabis plant extract provides pain relief for patients after 
major surgery, research has shown.

An Imperial College London team tested the extract - Cannador - on 65 
patients after surgery such as knee replacements and found it helped 
manage pain.

The researchers believe the results could lead to new pain relief 
drugs, even though the chance of side effects increased with stronger doses.

The research appears in the US journal Anesthesiology.

Lead researcher Dr Anita Holdcroft said: "Pain after surgery 
continues to be a problem because many of the commonly used drugs are 
either ineffective or have too many side effects.

"These results show that cannabinoids are effective and may lead to 
the development of a wider range of drugs to manage post-operative pain."

The researchers tested Cannador in different doses on 65 patients who 
had previously undergone surgery.

While all 11 patients who received a 5mg dose of the drug requested 
additional pain relief, only 15 of the 30 who received the 10mg dose 
and 6 of the 24 on the 15mg dose did so.

Side Effects

However as the dose increased some patients reported increased side 
effects such as nausea and increased heart rate.

Professor Mervyn Maze from Imperial College London, who also worked 
on the study, said: "We thought cannabis might be beneficial in 
helping manage pain following surgery, as previous research indicated 
cannabinoids help 'top up' the body's natural system for reducing 
pain sensation.

"This research proves it can be effective, with minimal side effects 
at low doses."

GW Pharmaceuticals, a Salisbury-based firm, is developing 
cannabis-based medicines under licence from the UK government.

One of its products, Sativex, has already been licensed in Canada for 
pain control in people with multiple sclerosis, and trials of the 
drug's ability to provide pain relief for people with advanced cancer 
are continuing.

Mark Rogerson, a company spokesman, said: "This latest trial is 
another welcome contribution to the body of evidence that 
cannabinoids have a role to play in medicine." 
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MAP posted-by: Richard Lake