Pubdate: 15 Mar 1997 Source: Chris Clay Author: John P. Morgan, M.D. Note: MAP is archiving each of the affidavits filed in the Chris Clay Constitutional Challenge to preserve these important documents. Bookmark: http://www.mapinc.org/clay.htm (Clay, Chris) ONTARIO COURT OF JUSTICE (GENERAL DIVISION) (Southwest Region) B E T W E E N: HER MAJESTY THE QUEEN Respondent -and- CHRISTOPHER CLAY Defendant AFFIDAVIT OF JOHN P. MORGAN M.D. I, JOHN P. MORGAN, Professor of Pharmacology, of the State of New York, MAKE OATH AND SAY AS FOLLOWS: 1. I am a Professor in the Pharmacology Department at CUNY Medical School in New York City. I have studied cannabis and its effects for over 25 years. I regularly review medical literature regarding cannabis, toxicity, and the medicinal use of cannabis. I have written and published eight articles that focus on and/or relate to cannabis and its use. 2. Attached hereto as Exhibit "A" is a copy of my Curriculum Vitae which outlines my professional and academic qualifications including a list of my publications which focus upon the study of cannabis sativa. 3. In the course of my research I have discovered that marijuana has various therapeutic uses. For example, it is useful in the treatment of nausea and vomiting for patients who suffer from the side effects of chemotherapy and AJDS. Marijuana helps combat HIV-related wasting because it helps patients become hungrier and thus, makes them less susceptible to massive weight loss. Marijuana is also useful in that it helps to lower intra-ocular pressure in glaucoma patients. Additionally, marijuana has a beneficial effect on individuals with spinal cord injuries and victims of muscular sclerosis since it helps relax muscle tone and muscle spasm. These views are generally accepted in the scientific community by those individuals who have studied and performed experiments with respect to the effects of marijuana. 4. Although marijuana is not without its potential harmful effects, these effects have been grossly exaggerated in contemporary society. In my article (co-authored with Professor Lynn Zimmer) Exposing Marijuana Myths: A Review of the Scientific Evidence (The Lindesmith Centre, 1995), I have summarized some of the major myths regarding the effects of marijuana that exist today. Attached hereto as Exhibit "B" is a copy of the aforementioned article that deals with the myths surrounding marijuana use and its effects. 5. There are significant difficulties with the current state of scientific experimentation with marijuana and the results that have been obtained from such experimentation. First, there is an enormous difficulty in making definitive statements concerning the effect of marijuana on human subjects. Specifically, there is difficulty in accepting statements which comment on the effect of marijuana on a human's brain since, to the best of my knowledge, no one has ever done a focused autopsy on a human being who was an avid marijuana smoker. Secondly, there is little experimentation done, in general, concerning the effect of marijuana on human subjects. Most experimentation has been and continues to be done on lab animals and cellular cultures. In fact, even when individuals who are willing to perform marijuana experimentation on human beings, such as Doctor Donald Abrams in California who was willing to undertake experimentation with AIDS patients, the government is unwilling to provide standard marijuana. Finally, there are difficulties in accepting evidence of the harmful effects of marijuana on the human fetus during pregnancy since experimentation has primarily been conducted on lab animals not on human subjects, and there are problems in extrapolating the results from lab animals to human beings. 6. Although the majority of marijuana experiments have been done on lab animals and cell cultures, there have been a few studies done on human populations. Chronic marijuana smokers in Jamaica, Costa Rica and Greece have been the subject of scientific study, and all three experiments yielded similar results by comparing the health of frequent users of marijuana to non-users. Psychological testing and clinical testing was performed during the course of these experiments. The data collected in these experiments illustrated that marijuana use caused little or no physical or emotional harm to the group of frequent users. As well, in Ganja in Jamaica, a study done by Comitas and Rubin, the experiments revealed that marijuana use did not alter the frequent users' attitude with respect to work and work ethic. 7. With respect to assertions that marijuana is a far greater health risk than tobacco, it should be noted that marijuana and tobacco smoke have very similar chemical compositions except that one contains cannabinoids and the other has nicotine. Marijuana is smoked by using deep inhalations rather than shorter inhalations that are used when smoking a cigarette. Thus, the smoking of a single marijuana cigarette deposits more irritants into the human body than the smoking of a single cigarette. However, one must consider that a "heavy" marijuana smoker may smoke 5 marijuana "joints" per day (most smoke less) as compared to a heavy cigarette smoker who smokes about 40 cigarettes per day. Therefore, it is obvious that the heavy cigarette smoker deposits more irritants into the human body. There has been no documented evidence of cancer in those smoking only marijuana. Cigarette smoking has been proven to cause not only cancer, but chronic bronchitis and emphysema, neither of which are documented side effects of marijuana smoking. 8. There is no convincing data to illustrate that marijuana impairs the functioning of the human immune system. In the early 1970's, a well-publicized study by Dr. Nahas indicated that there was some impaired immune responsiveness from the consumption of marijuana; however, Dr. Nahas has never been able to replicate the results of this study. Other scientists have attempted to replicate these findings to no avail. It has been demonstrated that animals exposed to extremely high dosages of THC did have a higher take-rate of certain viruses (e.g. herpes); however, no evidence of increased susceptibility to infection has been shown in human studies. 9. Thousands of studies have been done in an attempt to prove that marijuana harms sexual maturation and reproduction in humans, but there is no conclusive evidence to prove this contention. There may be, however, a brief decrease of sex hormone level acutely in the brain, but this level returns to normal soon after even without the cessation of marijuana smoking. 10. There is some literature that suggests that pregnant mothers who smoke marijuana during their pregnancy have babies who are small in terms of weight. However, one must take into account the fact that most of these women were poverty stricken and were heavily involved with alcohol, cigarettes and other drugs. There is no convincing evidence that reveals marijuana as the cause of birth defects to the fetus. 11. There is no conclusive proof that marijuana use causes brain damage in humans. In the early 1970's, Dr. Campbell conducted a study indicating some brain damage being caused from heavy marijuana exposure; however, hundreds of studies have been done in an attempt to replicate these results with no success. In the late 1980's the National Centre for Toxicology in Arkansas conducted an experiment in which monkeys were exposed to large dosages of marijuana for one year and no evidence was found of brain damage from this exposure. 12. Marijuana is almost always used in an experimental fashion. Marijuana is primarily used for occasional recreation and the vast majority of consumers do not experience any type of dependency. In fact, there is little evidence that suggests human physical addiction caused by marijuana use. A study done by Billy Martin in the U.S. was conducted in a laboratory where animals were given a steady infusion of THC and then, after a period of time, a cannabinoid receptor blocking drug was given. The only side effect of the cessation was a brief withdrawal period, however, one must understand that the average human marijuana user does not consume a quantity of marijuana as large and as consistently as the animals in this experiment did. 13. There is no conclusive proof to the contention that marijuana produces an amotivational syndrome in human beings in which individuals, because of marijuana, withdraw from attempts to succeed in society. Many experiments have been done since 1971, and none have conclusively proved that marijuana caused an amotivational syndrome. 14. Marijuana consumption is not a major cause of highway accidents. Most of the drug-related highway accidents involved alcohol and not marijuana. A recent study by Dr. Robbe in the Netherlands revealed that marijuana use prior to driving was safer than the ingestion of antihistamines before driving. He concluded that the psychomotor effect of marijuana does not precipitate bad or overzealous driving. 15. There is no evidence that marijuana is a "gateway" to the use of other drugs. I believe that this "gateway" theory is an admission that marijuana on its own is not a harmful drug. A recent high school survey done in the U.S. revealed that of the 38% of graduates who tried marijuana, only 16% of them went on to try cocaine. Thus, for 84% of high school seniors, marijuana is a terminus, not a gateway, drug. 16. There is no proven criminogenic potential of cannabis. There has been no documented evidence that suggests that marijuana drives individuals to a life of crime or that individual commit crimes in order to satisfy' their need to consume cannabis. 17. Although cannabis is prohibited by the Narcotic Control Act in Canada, the term narcotic is not a scientific term. Narcotic refers to a drug that causes stupor or has the potential to put people to sleep. This term has been used by legislatures to describe all types of dangerous substances in the U.S., Canada, and Europe, whereas the term narcotic has been limited in the scientific realm to the derivatives of the opiate poppy. In my experience, I have never used the term "narcotic" to refer to anything other than morphine and related compounds. 18. The three categories of drugs in the Narcotic Control Act- opiates, coca, and cannabis - all come from plant substances. They are often used as recreational drugs, yet they have very dissimilar effects. For example, many people have died from overdoses of opiates. Conversely, no one has ever died from an overdose of cannabis. Opiates cause slowing of the heart rate, stupefaction and sleep. Coca causes increase of heart rate with stimulation. Cannabis causes increase of heart rate with a corresponding drowsiness but not stupefaction. In addition, coca regularly raises the blood pressure whereas cannabis and the opiates do not. In terms of addiction, it is clear that opiates and coca are more harmful than cannabis. Cannabis is less harmful because it produces little in the way of deleterious physical impact. In my experience, there does not exist a sound scientific basis for classifying these three substances under the generic heading of "narcotic". 19. The significant difference between opiates, coca and cannabis is underscored by the fact that most "lay" people and jurists divide the drugs into "hard" and "soft" categories. The term "hard drugs" refers to more dangerous drugs, such as cocaine and heroin, which have highly addictive capacities and lead to significant physiological damage. The term "soft drugs" refers to drugs like cannabis and hashish, which are less likely to produce addiction and physiological harm. SWORN BEFORE ME ) at the City of ) in the ) this day ) of March, 1997 ) DR. JOHN P. MORGAN