Source: Washington Post Contact: http://washingtonpost.com/wp-srv/edit/letters/letterform.htm Website: http://www.washingtonpost.com/ Pubdate: Saturday, April 4, 1998 QUESTIONABLE NEEDLE EXCHANGES The March 25 front-page story "Pr. George's Needle Plan Wins Vote" carries the claim that "numerous federally funded studies have shown that needle exchange programs nationwide have helped reduce new HIV infections." This overstates the scientific status of the effectiveness of those programs. The difficulty of conducting careful epidemiology research among heroin addicts has been seriously underestimated. Though some scientific bodies have offered endorsement of needle exchange programs, all of the studies to date suffer from serious methodological limitations, including self-selection and self-reporting biases, inadequate samples, improper controls and limited proxy measures. In fact, the most recent and large-scale study, conducted in Montreal using a sophisticated observational design with prospective and case-control methods, found a consistent and independent positive association between attendance of needle exchange programs and risk of HIV infection. Moreover, the promising figures the story cites from Baltimore may not be reliable. The data are non-published and ignore the fact that surrounding counties, with which Baltimore's 20 percent putative decline in new HIV infection is contrasted, have a dramatically lower level of HIV prevalence. Health and Human Services Secretary Donna Shalala is correct to insist that support for needle exchange programs must await more convincing science. To err on this issue without strong evidence that dispensing needles to the addicted will neither place them at greater risk for HIV nor enhance the legitimacy of hard drug use would be to perpetrate a public health tragedy. DAVID MURRAY BRYAN KIM Statistical Assessment Service Washington © Copyright 1998 The Washington Post Company