Pubdate: 22 Nov 1998 Source: Boston Globe (MA) Contact: Website: http://www.boston.com/globe/ Copyright: 1998 Globe Newspaper Company. Author: Alan Leshner MARIJUANA ISN'T A HARMLESS DRUG Before Thomas Clark advocates the use of marijuana in moderation or suggests policy changes toward that end, he needs to look more closely at the scientific facts ("A realistic prescription," Focus, Nov. 1). In the first place, classifying drugs as either "hard" or "soft" is off the mark. All drug use is potentially dangerous for many people, and it is impossible to predict who will respond particularly badly. Marijuana is neither "soft" nor "benign"; rather, it is a drug with a high potential for abuse. In fact, every year more than 100,000 people, many of them adolescents, seek treatment for their inability to control their marijuana use. Most people who are knowledgeable about addiction would qualify this as an addictive drug. Another science-based reason for not condoning marijuana use comes from a recently published study by a Harvard researcher showing that use of any illicit drug, but especially marijuana, significantly increases the probability that an individual will abuse other drugs during the course of a lifetime. Moreover, science has shown that short-term use modifies learning, memory, emotional state, perception, and the motor skills necessary to drive a car. And studies have shown that prolonged use can alter the lungs and immune system in ways that last long after the individual has stopped using marijuana. The bottom line is that marijuana is not a benign drug, and its use should not be encouraged. Alan Leshner Director National Institutes of Health Rockville, Md. - --- Checked-by: Richard Lake