Pubdate: Tue, 1 Dec 1998 Source: West Australian, The (Australia) Page: 13 Fax: +61 8 94823830 Author: Rosco Woods THE OTHER SIDE OF NALTREXONE THE two main points of Norman Aisbett's report A trial for life (Big Weekend, 28/11) were that naltrexone is a miracle drug and that Dr George O'Neil is a saint. However, neither claim holds up to scrutiny when it is compared with results of a symposium on naltrexone held only three weeks ago in Sydney in conjunction with the National Methadone Conference. Dr James Bell, one of Australia's leading lights on addiction studies, paints a different picture of treatment from that of Dr O'Neil. He quotes horrendous retention rates, with 30 per cent to 50 per cent of addicts dropping out in the first two weeks. Indeed one clinical trial done by Malcolm Young of Sydney's Langton Centre has retention rates of 26 per cent and 7 per cent in two groups, Dr Bell gives an unbiased summary and says: "naltrexone should not be registered until much more research is done and much better outcomes are proved. The jury is out and rightly so." His words, coupled with the facts that we still don't know what naltrexone does to the liver and chances of overdose are greatly increased when stopping naltrexone treatment, should indicate that this treatment, when compared to the proved methadone program, should be put on hold. The other thing that concerns me about the Big Weekend report was some of the claims of Dr O'Neil's clients. Statements like "he has an aura of positivity", he "radiates goodness" and even "if there is a God, he is definitely working out of this clinic". One must wonder whether these "groupies" had been given some of naltrexone's history before they started their treatment. Did Dr O'Neil tell them that naltrexone has been used in more than 20 countries and before its claim as a heroin treatment, it was used for such diverse ailments as autism, chronic fatigue syndrome, HIV, eating disorders, hormonal disorders and even (before Viagra) erection problems? Very rarely would I agree with the Federal Government but the Federal Minister for Health is right not to be impressed by naltrexone. ROSCO WOODS, Leederville. - --- Checked-by: Patrick Henry