Pubdate: Thu, 18 Mar 1999 Source: Miami Herald (FL) Copyright: 1999 The Miami Herald Contact: http://www.herald.com/ Forum: http://krwebx.infi.net/webxmulti/cgi-bin/WebX?mherald Author: Usha Lee McFarling, Herald Washington Bureau Note: Part below starting at: "A Florida glaucoma patient, Elvy Musikka of Hollywood, started using marijuana in 1976. She started getting it legally prescribed after a 1988 court battle." U.S. EXPERTS ADVOCATE MARIJUANA FOR PATIENTS WASHINGTON -- Entering the fractious debate over medical marijuana, the nation's Institute of Medicine recommended Wednesday that marijuana cigarettes be made available for short periods to help cancer and AIDS patients who can find no other relief for their severe pain and nausea. Officials with the Department of Health and Human Services almost immediately responded by saying they would not dispense marijuana to individual patients until more clinical research showed it is safe. Still, the report was seen as a victory by many who advocate the use of marijuana as medicine. The response from drug-fighting groups was subdued. An explosion of recent scientific work, as well as patient anecdotes, shows that compounds in marijuana have potential to ease some of medicine's most intractable problems, said the report from the Institute of Medicine, an arm of the National Academy of Sciences. But its authors warned that smoking marijuana carries its own health hazards -- including lung damage and low-birth-weight babies -- and should be adopted only as a last resort after standard therapies have failed. Addiction was seen as a relatively minor problem likely to affect few users. To avoid the smoke, they called for new delivery systems, like inhalers, and for the development of pharmaceutical drugs made from or modeled after the active ingredients in marijuana, chemicals known as cannabinoids. ``Marijuana's future as a medicine does not involve smoking,'' said Dr. Stanley Watson, a neuroscientist and substance-abuse expert from the University of Michigan who co-authored the report. ``It involves exploiting the potential in cannabinoids.'' The endorsement pleased groups that have been working to make marijuana available to patients. Many were expecting a blander call for further research. ``It's a discreet but clear call to make marijuana available,'' said Ethan A. Nadelman, who directs the Lindesmith Center, a New York-based drug policy think tank. Report Is Called Tepid Other advocates, including the National Organization for the Reform of Marijuana Laws and Harvard Medical School Professor Lester Grinspoon, were more critical, calling the report ``tepid'' and ``political.'' They said it ignored the fact that many patients have successfully used marijuana as medicine for years with few harmful effects. Battles over medical marijuana have been fought across the nation since 1996, when California passed a ballot initiative that removed any state penalties from people who used marijuana for medicinal purposes. Since then, Arizona, Alaska, Oregon, Nevada and Washington state have passed laws permitting the use of medical marijuana. Some mainstream medical organizations, and the relatively conservative New England Journal of Medicine, have endorsed the use of medical marijuana. But last fall Congress overwhelmingly passed a resolution condemning the medical use of marijuana, and because federal law still outlaws marijuana use, many physicians are reluctant to prescribe it, even in states that have passed initiatives. `Nothing's Happened' ``There are so many strictures on doctors, so much uncertainty on the part of licensing boards . . . that nothing's happened,'' said Dr. John A. Benson Jr., a former dean of the Oregon Health Sciences University School of Medicine and the report's other co-author. Only eight patients in the United States have federal government permission to smoke marijuana for their conditions. They receive government-grown cigarettes under a ``compassionate use'' program no longer open to patients. A Florida glaucoma patient, Elvy Musikka of Hollywood, started using marijuana in 1976. She started getting it legally prescribed after a 1988 court battle. Her drugs are provided each month through her doctor at the Bascom Palmer Eye Institute. The drugs come from the National Institute of Drug Abuse on the campus of the University of Mississippi. Some glaucoma patients use marijuana to reduce pressure behind the eyes. ``I'd be blind'' without regular use of the drug, said Musikka, who is in her 50s. ``My life would have turned into a total disaster if I didn't do this. I would have become a tax burden. Instead, I have limited vision and I can get around on my own.'' Drug Director's Views The federal government's most visible opponent of medical marijuana has been White House drug-control director Barry McCaffrey. In campaigning against state marijuana initiatives, he said there was no proof that marijuana has medical benefits, that marijuana is a gateway drug that leads to abuse of drugs like heroin and that allowing marijuana to be used as medicine would increase illicit recreational marijuana use. McCaffrey, who heads the Office of National Drug Control Policy, commissioned the institute's $900,000 report in response to calls that federal drug policy on medical marijuana be changed. The study disarms some of McCaffrey's arguments. Its authors found no evidence that marijuana use caused people to progress to harder drugs or that medical use brought increases in recreational use. In a statement, McCaffrey said he would study the report's conclusions. He emphasized that there is some evidence that marijuana is addictive and can lead to further drug use. He left it to the nation's health agencies to judge whether more patients should be provided with marijuana cigarettes. - --- MAP posted-by: Richard Lake