Pubdate: Wed, 17 Mar 1999 Source: Argus Observer (Oregon) Contact: Argus Observer Website: http://www.argusobserver.com Author: AP SCIENTIFIC REPORT SAYS MARIJUANA MAY BE MEDICALLY USEFUL WASHINGTON (AP) -- The active ingredients in marijuana can help fight pain and nausea and thus deserves to be tested in scientific trials, a federal advisory panel said in a report sure to reignite the debate over whether marijuana is a helpful or harmful drug. The Institute of Medicine also said there was no conclusive evidence that marijuana use leads to harder drugs. In the past few years, voters in Alaska, Arizona, California, Colorado, Nevada, Oregon and Washington have approved measures in support of the medical marijuana, even through critics believe such measures send the wrong message to youth. Congress has taken a hard line on the issue, with the House last fall adopting by 310-93 vote a resolution that said marijuana is a dangerous and addictive drug and should not be legalized for medical use. Asked to examine the issue by the White House drug policy office, the institute,which is an affiliate of the National Academy of Sciences, said that because the chemicals in marijuana ease anxiety, stimulate the appetite, ease pain and reduce nausea and vomiting, they can be helpful for people with AIDS. The panel warned, through, that smoking marijuana can cause respiratory disease and called for the development of standardized forms of the drug, called cannabinoids, that can be taken, for example, by inhaler. "Marijuana has potential as medicine, but it is undermined by the fact that patients must inhale harmful smoke," Stanley Watson of the Mental Health Research Institute at the University of Michigan, one of the study's principal investigators said. Even so, the panel said, there may be cases where patients could in the meantime get relief from smoked marihuana, especially since it might take years to develop an inhaler. The White House Office of National Drug Control Policy said it would carefully study the recommendations. "We note in the report's conclusion that the future of cannabinoid drugs lies not in smoking marijuana, but in chemically defined drugs" delivered by other means, the office headed by retired General Barry McCaffrey said in a statement. One patient called the findings long overdue. "It's taken a long time, but I feel like now, people will stand up and listen," Irvin Rosenfeld, a Boca Raton, Fla., stockbroker who has smoked marijuana supplied by the federal government for 27 years because of a rare medical condition said. "When you have a devastating disease, all you care about is getting the right medicine ... and not having to worry about being made a criminal," Rosenfeld said. He suffers from tumors that press into the muscles at the end of long bones. The marijuana relaxes those muscles, keeping them from being torn by the tumors and allowing him to move with less pain. Rosenfeld is one of just eight people in the country receiving marijuana from the government because of unusual diseases. The panel urged clinical trials to determine the usefulness of marijuana in treating muscle spasms. While it has also been promoted as a treatment for glaucoma, the panel said smoking marijuana only temporarily reduces some of the eye pressure associated with that disease. Daniel Zingale of AIDS Action said he is "pleased that the study validates the benefits of medical marijuana." Chuck Thomas of the Marijuana Policy Project said the report "shoots down" claims that marijuana has no medical benefits. Opponents of allowing medical use of marijuana long have claimed that it is a "gateway" drug, giving people a start on the road to more dangerous drugs such as heroin and cocaine. The report concludes there is "no conclusive evidence that the drug effects of marijuana are casually linked to subsequent abuse of other illicit drugs." In fact, the report concludes, most drug users did not begin with marijuana but rather started by using tobacco and alcohol while they were underage. The New England Journal of Medicine has editorialized in favor of medical marijuana and the American Medical Association has urged the National Institutes of Health to support more research on the subject. An expert panel formed by NIH found in 1997 that existing research showed some patients could be helped by the drug, principally to relieve nausea after cancer chemotherapy or to increase AIDS patients' appetites. The drug also has helped some patients control glaucoma, that panel found. - --- MAP posted-by: Patrick Henry