Pubdate: Thu, May 13 1999 Source: The Associated Press (OR) Copyright: 1999 The Associated Press Website: http://www.oregonlive.com/ Forum: http://forums.oregonlive.com/ Author: Brad Cain, AP OREGON DOCTORS ARE WARY OF PRESCRIBING MARIJUANA * Despite The New State Law, They Fear Prosecution And Are Concerned About Harm To The Smoker's Lungs SALEM -- Despite Oregon's new medical marijuana law, many doctors treating cancer and AIDS patients still fear they risk prosecution if they recommend something the federal government considers illegal. Still others are concerned that they might be doing their patients more harm than good with a drug that is smoked into the lungs. In increasing numbers, doctors are turning instead to federally approved drugs such as Marinol, a synthetic version of THC, the key chemical component in marijuana. Even though the drug has been available for years, the manufacturers of the drug, Columbus, Ohio-based Roxane Laboratories, said Marinol use has risen since six states including Oregon approved the use of medical marijuana with a doctor's consent. The company says about 10,000 patients use the prescription drug nationwide. In Oregon, statistics are limited. But one indicator is the Oregon Health Plan, which covered more than twice as many Marinol prescriptions in the first three months of this year as it covered during the same period in 1998. "The problem I have with medical marijuana is that as a physician you like to know what the potency of the agent is. Is it prepared appropriately?" said Dr. William Pierce, a Salem oncologist. "And then there's the whole smoking thing and putting a gas into one's lungs. There may be people with lung conditions who shouldn't consume it." That was the case with John Derdenger of Salem, who lost his appetite and 40 pounds after two surgeries to remove a cancerous bladder. Derdenger thought about using medical marijuana to combat nausea and increase his appetite. But his doctors steered him to Marinol because they feared smoking marijuana could further irritate his lungs, which are already scarred by emphysema. There is a quiet debate among some doctors and proponents of the law about the capsule versus the medical value of the weed. Supporters of Oregon's medical marijuana law say Marinol is only the first step in the right direction. It is the only agent, or cannabinoid, in marijuana that has undergone research and been developed into a prescription drug. Patients who use marijuana are able to get the benefits of dozens of other agents in marijuana, proponents of the law argue. "I look at Marinol as a prototype," said Dr. Rick Bayer, the chief petitioner of Oregon's law. "It's just the beginning. It's the first isolated cannabinoid. I'd like to see the most beneficial ones available in different forms including pills, inhalers and patches." - --- MAP posted-by: Jo-D