Pubdate: Sun, 01 Aug 1999 Source: Danbury News-Times Copyright: 1999 The Danbury News-Times (CT) Contact: 333 Main Street Danbury, CT 06810 Fax: (203) 792-8730 Website: http://www.newstimes.com/ Author: Henry N. Blansfield METHADONE TREATMENT HELPS ADDICT AND COMMUNITY Thanks to rapid advances in the science of neurochemistry, it is becoming apparent that chemical dependency--addiction, if you will--possesses similarities to mental illnesses such as depression, obsessive-compulsive disorder and schizophrenia insofar as their biochemical origins are concerned. These conditions seem to be related to certain changes in the levels of neurotransmitters, including serotonin, norepinephrine and dopamine. Nerve cells communicate between one another by secreting these chemicals, which then bind or connect to an adjacent nerve cell. Evidence is accumulating that the chemically dependent are suffering from an illness brought about by modifications in the actions of neurotransmitters and the nerve cell wall receptors upon which they act. Drugs that induce and enhance pleasurable feelings--including heroin, cocaine, alcohol and nicotine--do so by altering the re-uptake of specific neurotransmitters or, in some instances, changing the receptor or dock to which the transmitters attach. That these changes occur is demonstrated by the development of tolerance to alcohol and other drugs so that larger and larger amounts have to be taken to get the same effect, symptoms of withdrawal when alcohol and other drug use is stopped, and craving for the chemical of choice when abstinent. Repeated use over time of pleasure-enhancing drugs, including alcohol, bears the risk of development of these brain changes that may persist or be slow to normalize. Changes in brain function induced by alcohol and other drugs fit a medical paradigm. Chemical dependency is a disease unfortunately occurring as a result of injudicious use of pleasure-producing agents. The risk of brain damage must become the focal point of attempts to educate our youth. The emphasis on moral and ethical considerations is not and adequate deterrent to "picking up" drugs or consuming alcohol. Heroin dependency is currently a problem for at least 500,000 people in this country and from all reports is growing rapidly. There have been a spate of overdose deaths recently due to the high potency of the heroin available on the street. Although many are snorting heroin to avoid the risks of injection, about one third of the cases of HIV infection occur among drug injectors. Drug injection also bears the risk of bacterial contamination and viral hepatitis B and C. Despite participation in treatment programs emphasizing abstinence, either long or short term, the relapse rate for heroin use is 85 to 90 percent. Since 1968, following the research done by Dr. Vincent Dole and Dr. Marie Nyswander in New York City, methadone has been used to return relapsing heroin-dependent people to a comfortable, functioning lifestyle. Heroin addicts on adequate doses of methadone are freed from craving and the symptoms of withdrawal. They are "normalized." If the dose of methadone is at optimum levels, "shooting up" will not produce an additional high. Methadone was develped in Germany during World War II as a substitute for morphine. It is a drug of the same class as heroin, an opiate. It has a slow, even metabolism over 24 hours so that there are minimal highs and lows. Heroin injection, which has a short metabolic life, may be needed four to seven times a day and is accompanied by periods of nodding, interspersed with withdrawal symptoms and craving for more. Methadone has the immense advantage of being given orally once daily. This obivates the need to inject the drug. The risk of HIV and other blood-borne diseases is considerably lessened. It is true that the opiate-dependent status of those on methadone is maintained. But the object of successful medical treatment is to return sick people to a more productive lifestyle. Patients on methadone are able to work, support their families, go to church, vote, play and watch sports just like you and me. They are able to avoid the drug black market and the criminality associated with it. People who are adequately dosed on methadone no longer seek drugs from other sources. There is no further need to rob and steal to support a drug habit. Methadone treatment may need to be continued indefinitely, just as diabetics may need insulin daily for the rest of their lives. Because of irrational fear, and loathing for drugs and drug users, society tends to stigmatize, debase and discriminate against those people who are identified as addicts. This explains the "not in my back-yard" phenomenon when it comes to establishing a treatment facility in any neighborhood. The reality is that heroin addicts who elect methadone treatment want to change their lives, want to better their social and workplace conditions and want to abandon the horrors of past drug-seeking criminal behavior. The methadone treatment programs distribute the drug daily as a liquid consumed in full view of clinic personnel in order to avoid the risk of diversion. They have rules that prevent congregating or loitering in the clinic area. The clinics have ancillary psychological, medical and social services which are designed to help patients improve their general physical and mental health. For instance, a medical examination may reveal signs and symptoms of HIV infection, hepatitis or tuberculosis, all of which are treatable. In this way, the public health is dramatically benefited by methadone treatement. In summary, heroin addiction is a disease. It is treatable. Methadone has been proven effective for close to 30 years. Wisdom dictates its widespread use and an expansion of its availability. - --- MAP posted-by: Derek Rea