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Pubdate: Sat, 26 Mar 2005 Source: Ottawa Citizen (CN ON) Copyright: 2005 The Ottawa Citizen Contact: http://www.canada.com/ottawa/ottawacitizen/ Details: http://www.mapinc.org/media/326 Author: Sharon Kirkey Referenced: http://www.mapinc.org/drugnews/v05/n321/a05.html?40344 Cited: Multidisciplinary Association for Psychedelic Studies http://www.maps.org/ HEADACHES FUEL REVIVAL OF HALLUCINOGENIC MEDICINE Doctors Look At Magic Mushrooms And LSD As Possible Cures For A 'Terrible Affliction,' Writes Sharon Kirkey. The pain strikes without warning in the middle of the night, an explosive shot of pain on one side of Doug Wright's head that feels "like a red hot poker suddenly stuck through my eye." He bolts from bed. He can't lie down, he can't sit still; he paces and moves, and if he can't abort the headache instantly by inhaling high-dose, high-flow oxygen from the tank he keeps in his house, he drops to his knees, screaming in agony. Twice he has blacked out from the pain. Mr. Wright, who turns 49 this year, has suffered from cluster headaches for 30 years. His are "episodic": Three to five headaches per day, for eight to 10 weeks' duration at a time. "Chronics" experience one to five headaches every day, day in and day out. "One of the old terms, if you go into medical sites for cluster headaches, is 'suicide headaches.' " Mr. Wright treats his using oxygen therapy and medicines that constrict the blood-vessel walls in his head. Psilocybin -- the key ingredient in "magic" mushrooms -- could be next. "Let me state up front that I have not tried this treatment, yet, myself. It's illegal. The last thing I want is some person banging on my door, questioning what I'm doing, or what's going on," the Nanaimo, B.C., chiropractor says. But, as Harvard University doctors prepare to test the hallucinogenic fungus, as well as LSD, against cluster headaches, Mr. Wright hopes to be involved. "I'm hoping that when the study comes up, I'll be in cycle, and I'll be down there," in Boston. "I'd like to participate, particularly if we can do it in a controlled, laboratory manner." Decades after another Harvard alumnus proselytized the healing powers of hallucinogens, research into psychedelic medicine is experiencing a re-awakening. But Timothy Leary wasn't advocating pain control: He pushed psychedelics as the path to enlightenment. Today, hallucinogens are on a path to redemption, with a small group of researchers studying LSD, magic mushrooms, MDMA (the drug used to make ecstasy) and even ibogaine, a psychoactive derived from the root bark of an African plant, as treatments for post-traumatic stress disorder, obsessive-compulsive behaviours, drug and alcohol addiction and anxiety and physical pain from terminal cancer. "It may not be long before doctors are legally prescribing hallucinogens for the first time in decades," a recent article in New Scientist magazine predicted. In addition to testing LSD and psilocybin for cluster headaches, researchers at Harvard University won U.S. Food and Drug Administration approval in December to test MDMA-assisted psychotherapy on eight people with advanced cancer. MDMA, or 3,4-methylenedioxymethamphetamine -- street-named ecstasy, Adam, XTC, hug, beans and love drug, according to the U.S. National Institute on Drug Abuse -- is a psychoactive. Studies on animals suggest it works on serotonin, the brain chemical that regulates mood and sensitivity to pain. The work is being partly funded by MAPS, the Multidisciplinary Association for Psychedelic Studies based in Sarasota, Florida, whose mission is to support scientific research "designed to develop psychedelics and marijuana into FDA-approved prescription medicines, and to educate the public honestly about the risks and benefits of these drugs," according to its website. MAPS is supporting a preliminary study at the Iboga Therapy House near Vancouver to test ibogaine (which is not a controlled substance) in treating cocaine, crack, alcohol and other chemical addictions. Anecdotal and case reports suggest magic mushrooms or LSD may not only reduce pain from cluster headaches, but also stop the cycling course of attacks. According to Dr. John Halpern, an instructor in psychiatry at Harvard Medical School who is heading the LSD/psilocybin cluster-headaches study, no conventional medications exist that can do that. In Canada, the non-profit Organization for Understanding Cluster Headache (OUCH) Canada, which Mr. Wright helped found, is disseminating information and links to the studies on its website (www.clusterheadaches.ca) "There are, I'm sure, medical doctors (in Canada) who are monitoring it and waiting to see the outcome of the trials," Mr. Wright says. "This is a terrible affliction. We're looking for some way to end our pain." - --- MAP posted-by: Jay Bergstrom